Koala retrovirus (KoRV): molecular biology and evolution
نویسندگان
چکیده
منابع مشابه
Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV)
Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1) is a well-known example. The gibbon ape leukaemia virus (GaLV) and koala retrovirus (KoRV), two gammaretroviruses, are also the result of a transspecies transmission, however from a still unknown host. Related retroviruses have been found in Southeast Asian mice although the sequence si...
متن کاملA Novel Exogenous Retrovirus Isolated from Koalas (Phascolarctos cinereus) with Malignant Neoplasias in a United States Zoo
Koalas in US zoos were screened for koala retroviruses in an effort to determine the viral mechanism for koala retrovirus induced malignant neoplasias. Although the previously characterized koala retrovirus (KoRV-A) was present in all US koalas, some koalas were also infected by a novel koala retrovirus, termed KoRV-B. The genome of KoRV-B is highly related to KoRV-A; however, certain regions w...
متن کاملTransspecies transmission of the endogenous koala retrovirus.
The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods fo...
متن کاملKoala Retrovirus in Free-Ranging Populations — Prevalence
The prevalence of koala retrovirus (KoRV) provirus (DNA) and the average number of proviral insertions per cell vary in different free-ranging koala (Phascolarctos cinereus) populations across Australia. Populations in the northern states of Queensland and New South Wales have 100% proviral prevalence and mean proviral copy number of 140–165 per cell. In contrast, the proviral prevalence in the...
متن کاملIdentification of a novel subgroup of Koala retrovirus from Koalas in Japanese zoos.
We identified a new subgroup of koala retrovirus (KoRV), named KoRV-J, which utilizes thiamine transport protein 1 as a receptor instead of the Pit-1 receptor used by KoRV (KoRV-A). By subgroup-specific PCR, KoRV-J and KoRV-A were detected in 67.5 and 100% of koalas originating from koalas from northern Australia, respectively. Altogether, our results indicate that the invasion of the koala pop...
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ژورنال
عنوان ژورنال: Technical Reports of the Australian Museum, Online
سال: 2014
ISSN: 1835-4211
DOI: 10.3853/j.1835-4211.24.2014.1607